Fig. 1. Identification of KLF5 as a positive regulator for DSG3.

a Scheme of the CRISPR/Cas9 sgRNA library screen. b Scatterblot showing genes and according to p-values by comparison of the DSG3^low versus DSG3^high pools. Fold changes are indicated by the dot size. c Scheme of DSG3 promoter screen. d Scatterblot of genes enriched at the DSG3 promoter blotted according to fold change and p-value. e Overlap of positive regulators identified in CRISPR/Cas9 sgRNA library screen and proteins binding to the DSG3 promoter identified by promoter pulldown. Source data are provided as a Source Data file.