Fig. 3.

A–C Average edge density, global efficiency and local efficiency of the FC network under different medications andl for different correlation thresholds σ. We found reduced edge density and reduced global and local efficiency in the alprazolam condition compared to baseline, and the placebo and etifoxine conditions. In (D) a reduction of the rich-club coefficient due to administration of alprazolam can be observed. Regions, where the difference to alprazolam becomes significant, are indicated in bars above, with the respective colours for the placebo, etifoxine and baseline condition. Error bars represent 95% confidence intervals across subjects. Significant differences between conditions in (A–C): *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, ns not significant, (ns): not significant after false discovery rate correction. Bars in (D) indicate regions where a significant difference to alprazolam can be observed with p ≤ 0.05.