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. 2024 Sep 13;7:1132. doi: 10.1038/s42003-024-06839-6

Fig. 1. ICVB-1042 is an E2F-dependent oncolytic adenovirus composed of an Ad5 backbone with genomic modifications.

Fig. 1

1. ΔLXCXE = mutation preventing binding of E1A to retinoblastoma (pRb) restricting virus to cells with high E2F activity. 2. Hexon E451Q point mutation to evade liver sequestration by the complement Factor X thus enabling intravenous dosing. 3. Deletion of several E3 genes (Δ12.5 K, ΔCR1a0, Δgp19k, ΔRIDa, ΔRIDb, Δ14.7 K) to enhance viral cytotoxicity in tumor cells. 4. Chimeric Ad5 fiber with Ad34 knob for enhanced tropism. 5. YPet-P2A-ADP to allow visualization of viral infection. Ad5 adenovirus serotype 5, Ad34 adenovirus serotype 34, ADP adenovirus death protein, E1A early region 1A, E3 early region 3, E2F early region 2 transcription factor, E4orf6/7 early region 4 open reading frame 6/7, IV intravenous, YPet yellow fluorescent reporter protein. Also refer to Supplementary Table 1. Figure created with BioRender.com.