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. 2024 Sep 13;7:1132. doi: 10.1038/s42003-024-06839-6

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Human plasma membrane proteins (6101 full-length proteins and 396 heterodimers) were screened in technical duplicate for binding to ICVB-1042 and Wt Ad5 using the Retrogenix™ Cell Microarray Technology. Subsequent confirmatory screening (n = 34 interactions) in technical duplicate revealed specific binding of ICVB-1042 to CD46 isoform D and CD46 isoform A while Wt Ad5 bound to CXADR (CAR) and glycoprotein 2 (GP2). Neither virus specifically bound to desmoglein 2 (DSG2). b–d YPet fluorescence on CD46+ A549 and CD46− A549 cells were assessed following incubation with ICVB-1042 or Ad5-YPet (24 h at MOI = 10) by flow cytometry. b Representative flow cytometry plots showing YPet fluorescence on CD46+ A549 and CD46− A549 cells. c Percentages of YPet+ cells. Bars represent means of technical duplicates. d Relative percentage of YPet+ cells within CD46− A549 cells, normalized to percentage of YPet+ cells within CD46+ A549 cells.