Table 1.

GC immune microenvironment containing various cell subtypes

Cell types	Subtypes	Gene signatures	References
T cell		CD3D, CD3E	[54]
Activated T cell		CD69	[69]
Proliferative T cell		CCNB2, DLGAP5, MKI67	[69]
CD4+ T cell	Naïve CD4+ T cell	CCR7, LEF1	[58]
	CD4+ Tex cell	PDCD1, CXCL13, TIGIT	[58, 69]
	CD4+ TEM	CCL5, ANXA1, GZMA	[58]
	CD4+ Treg	FOXP3, CTLA4	[58]
	GADD45B+ Th1-like CD4+ T cell	GADD45B, TNF	[58]
	CD4+ Tconv cell	LAYN, TNFRSF9, IL2RA, CCR8, CTLA4	[70]
CD8+ T cell	Naïve CD8+ T cell	LEF1, SELL	[58]
	CTL	NKG7, GZMA, GNLY	[58, 69]
	CD8+ Tex cell	CTLA4, LAG3, TIGIT	[58]
	CD8+ TEM	GZMK, CXCR4, EOMES	[58]
	MAIT cell	SLC4A10, KLRB1	[58]
	Tc17	IL17, CXCL12	[71]
Treg cell		FOXP3, ICOS, CTLA4	[58, 69]
B cell		CD79B, MS4A1, CD79A	[35, 54]
	CXCR4+ B cell	CXCR4	[72]
NK cell		KLRC1, KLRF1	[54]
	CD8− NK cell	NKG7, GZMA	[69]
Macrophage		CD14	[35]
	SPP1+ TAM	GDF15	[63]
	CTShigh TAM	CTSA, CTSD, CXCL2, LAMC1, NRP1	[55]
	C1Qhigh TAM	C1QA, C1QB, C1QC	[55]
DC		CD1C	[69]
	cDC1	CLEC9, XCR1	[54]
	cDC2	CLEC10A, CD1C	[54]
	Monocyte-like DC	CCL2, CCL3, CCL4, IL1B	[54]
Neutrophil		FCGR3B, CSF3R	[54]
Mast cell		CPA3	[35]
Fibroblast		COL3A1, COL1A2, ACTA2, NNMT,	[35, 54]
	Myofibroblast	ACTA2, MYH11	[73]
	Pericyte	RGS5, ACTA2	[73]
	eCAF	MMP14, LOXL2, POSTN	[73]
	iCAF	CXCL12, IL-6, CXCL14	[73]
	CXCR7+ fibroblast	CXCR7	[56]
	CAFEndMT	RGS5, ACTA2, PLVAP, VWF	[74]

Tex exhausted T cell, T_EM effector memory T cell, Treg regulatory T cell, Th1 T helper type 1 cell, Tconv conventional T cell, CTL cytotoxic CD8⁺ T cell, MAIT mucosal-associated invariant T cell, Tc17 IL-17 CD8⁺ T cell, NK natural killer cell, CTS^high cathepsin^high, TAM tumor-associated macrophage, C1Q^high complement 1q^high, DC dendritic cell, cDC conventional DC, CAF cancer-associated fibroblast, eCAF extracellular matrix CAF, iCAF inflammatory CAF, CAF_EndMT endothelial-to-mesenchymal CAF