Table 3.

Events of clinical interest

Event, n (%) ECI category ECI subcategory	N = 21
	All grades	Grades ≥3
Cardiac events∗	5 (23.8)	0
Atrial fibrillation	0	0
Ventricular tachyarrhythmias	0	0
Leukopenia	12 (57.1)	9 (42.9)
Neutropenia	10 (47.6)	8 (38.1)
Other leukopenia	4 (19.0)	2 (9.5)
Thrombocytopenia	1 (4.8)	0
Hemorrhage†	7 (33.3)	0
Hepatotoxicity	1 (4.8)	0
Hypertension	1 (4.8)	1 (4.8)
Infections‡	14 (66.7)	8 (38.1)
Interstitial lung disease/pneumonitis	1 (4.8)	0
Second primary malignancies	1 (4.8)	0
Second primary malignancies (excluding skin)	1 (4.8)	0

ECI, event of clinical interest.

^∗Cardiac events included 2 patients with tachycardia (both grade 2), 1 patient with cardiac failure and mitral and tricuspid valve incompetence (all grade 1), 1 patient with pericarditis (grade 1) and chronic cardiac failure (grade 2), and 1 patient with arrhythmia (grade 2).

^†Hemorrhage was reported in 1 patient with petechiae (grade 1), 2 patients with hemorrhagic diathesis (both grade 1), 3 patients with contusion (n = 3, grade 1; n = 1, grade 2), and 1 patient with epistaxis (grade 1).

^‡Six of the 8 grade ≥3 infections were related to COVID-19: 4 were grade 5 and 2 were grade 3.