Table 4.
Concentrations of amyloid Aβ1-42, Aβ1-40, total tau protein, phosphorylated tau protein (pT181), and amyloid Aβ1-42 /Aβ1-40 ratio in cerebrospinal fluid in the responder and non-responder groups immediately after external lumbar drainage placement (0`), after 36 hours, and after 72 hours of drainage
|
|
Responders (n = 10) |
Non-responders (n = 10) |
P |
||
|---|---|---|---|---|---|
| median | range | median | range | ||
| Aβ1-42 (pg/mL) |
|
|
|
|
|
| 0` |
224.535 |
71.99-1486.14 |
122.285 |
42.86-481.24 |
0.579 |
| 36 h |
373.5 |
183.8-1386.78 |
242.435 |
15.24-409.89 |
0.052 |
| 72 h |
476.52 |
96.19-580.41 |
168.755 |
42.86-391.52 |
0.043 |
| Aβ1-40 (pg/mL) |
|
|
|
|
|
| 0` |
1668.76 |
384.28-14250.56 |
3621.33 |
341.13-11462.74 |
0.436 |
| 36 h |
3336.72 |
1137.97-22197.72 |
5164.27 |
1064.94-8969.21 |
0.796 |
| 72 h |
2756.75 |
424.6-21188.43 |
4721.04 |
384.28-10134.47 |
0.720 |
| Aβ1-42/Aβ1-40 |
|
|
|
|
|
| 0` |
0.14183 |
0.03153-0.22653 |
0.05037 |
0.02381-0.12564 |
0.007 |
| 36 h |
0.11842 |
0.02858-0.21062 |
0.04065 |
0.00686-0.22069 |
0.019 |
| 72 h |
0.16955 |
0.02529-0.23922 |
0.04845 |
0.01927-0.11153 |
0.008 |
| t- tau (pg/mL) |
|
|
|
|
|
| 0` |
150.85 |
55.72-334.99 |
163.24 |
22.69-331.34 |
0.796 |
| 36 h |
257.905 |
138.1-420.49 |
319.77 |
77.51-693.76 |
0.481 |
| 72 h |
235.9 |
55.72-455.39 |
339.1 |
15.77-1027.1 |
0.400 |
| pT181 (pg/mL) |
|
|
|
|
|
| 0` |
38.05 |
13.14-58.86 |
26.77 |
15.21-44.77 |
0.481 |
| 36 h |
47.15 |
30.90-108.78 |
44.06 |
23.57-107.53 |
0.912 |
| 72 h | 56.26 | 17.83-105.27 | 44.71 | 22.31-123.23 | 0.604 |