FIG. 1.

Schematic of the ICP27 protein showing locations of defined functional regions. These include NES, a putative nuclear export signal (open box); the acidic domain, involved in gene expression and DNA synthesis (striped box); NLS, nuclear localization signal (black box); NuLS, nucleolar localization signal (white box); RGG sequence, RNA binding motif (gray box); and activation and repression domains (arrows), which include a cysteine-histidine zinc-finger-like domain (checkered box). Italicized numbers define mutated sites (M11, M15, and M16) and the boundaries of in-frame deletions. Bold numbers correspond to relevant amino acid positions.