Table 2. Results of the heterogeneity test and the horizontal pleiotropy test.
Outcome | Genes | MR_pleiotropy_test Q_P value | MR_heterogeneity P value |
---|---|---|---|
Pancreatic cancer (bbj-a-140) | RECQL | 0.89 | 0.49 |
AP2B1 | 0.04 | 0.06 | |
MVP | 0.70 | 0.33 | |
EIF2AK2 | 0.84 | 0.78 | |
BCAS1 | 0.83 | 0.31 | |
ENO1 | >0.99 | 0.36 | |
MCM6 | 0.32 | 0.78 | |
PSEN1 | >0.99 | 0.75 | |
XPO1 | >0.99 | 0.98 | |
LYZ | 0.27 | 0.006 | |
SEC14L2 | >0.99 | 0.70 | |
PYGB | 0.18 | 0.06 | |
CORO1C | >0.99 | 0.93 | |
ACTR3 | 0.91 | 0.74 | |
STAT1 | 0.92 | 0.04 | |
SLC25A12 | >0.99 | 0.94 | |
ATP8A1 | 0.99 | 0.43 | |
PALLD | 0.56 | 0.005 | |
ACTN4 | 0.98 | 0.81 | |
CAP1 | >0.99 | 0.86 | |
RAP1GAP2 | 0.64 | 0.46 | |
MYH11 | >0.99 | 0.86 | |
LCP1 | 0.92 | 0.07 | |
KIF23 | 0.72 | 0.04 | |
TMOD3 | 0.38 | 0.001 | |
BRCA2 | 0.99 | 0.96 | |
PML | 0.95 | 0.12 | |
CDC42BPA | 0.99 | 0.18 | |
RALB | 0.99 | 0.52 | |
SCD5 | 0.47 | 0.009 | |
CCNA2 | 0.97 | 0.75 | |
ITGB1 | 0.90 | 0.36 | |
ALB | >0.99 | 0.79 | |
PSMD1 | >0.99 | 0.50 | |
SPATS2L | 0.16 | 0.05 | |
KIF13B | 0.81 | 0.47 | |
ECI2 | 0.27 | 0.31 | |
INF2 | 0.39 | 0.09 | |
HSPA1B | 0.60 | <0.001 |
MR, Mendelian randomization.