Fig. 6.

Effects of gut microbiota on IDPs identified by IVW-MR and mediation analysis. a, Significant results with IVW P-value <0.05 (RE-IVW) and one of the additional three methods P-value <0.05 (weighted median, weighted mode, and MR Egger). Data were analyzed using IVW as the primary method and other three methods (weighted median, weighted mode, and MR Egger) as sensitivity analysis. The causal estimates are expressed as β values with 95% CI values. The width of the lines extending from the midpoint represent the 95% CI. Unadjusted P values (RE-IVW, weighted median, weighted mode, and MR Egger) are given. b, Schematic diagram of the brain regions in lateral, medial, and dorsal views. c-f, Significant results from the mediation analysis.