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Cysteine and methionine analogs as JMJD7 substrates. (a) Structures of cysteine/methionine analogs. LC–MS data showing potential for JMJD7‐catalyzed (2 μM) hydroxylation of DRG1 peptides (10 μM) in the presence of 2OG (10 μM), FAS (10 μM) and LAA (100 μM). (b) DRG1‐Cys, (c) DRG1‐D‐Cys, (d) DRG1‐hCys, (e) DRG1‐CysMe, (f) DRG1‐Met, (g) DRG1‐hMet, (h) DRG1‐MetO, (i) DRG1‐SeMet, (j) DRG1‐Sec, (k) DRG1‐Ser, (l) DRG1‐hSer, and (m) DRG1‐meOhSer.
