Scheme 1.
(a) MMTrCl, pyridine then Ac2O, DMAP; (b) 80% aq. AcOH; (c) 2-chloro-4H-1,3,2-benzodioxaphosphorin-4-one, pyridine–DMF; (d) bis(tri-n-butylammonium)pyrophosphate in DMF, Bu3N; (e) 1% iodine in pyridine–H2O then NH4OH.
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