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. 2024 Apr 16;47(5):100721. doi: 10.1016/j.bj.2024.100721

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© 2024 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 5 — Pharmacokinetics of ^99mTc-UCMSC-EVs (a) The representation of in vivo blood half-life fitting with a two-compartment model. The gray line is the fitting curve. The blood half-life was 0.85 ± 0.28 min in the distribution phase and 25.22 ± 20.76 min in the elimination phase (n = 6). (b) A representative plot of the AUC of ^99mTc-UCMSC-EVs is shown from the initial timepoint to 24 h postinjection. Collectively, the AUC of ^99mTc-UCMSC-EVs in blood was 1021.07 ± 397.77 kBq∗h/mL from administration to 24 h (n = 6).