Fig. 2.

CHOPINTEND scores (left diagram), HINE-2 scores (middle) and TC/HC ratio (right) as a function of age for the 27 SMA patients (2 deceased patients excluded). TC: thoracic circumference, HC: head circumference. Red lines represent SMA patients with two copies of SMN2, and blue lines represent SMA patients with three copies of SMN2. For comparative purposes, the CHOPINTEND score, HINE-2 score and TC/HC ratio of the two presymptomatic patients with more than 12 months of follow-up in June 2022 are shown as black lines in the figure