Fig. 4.

The mitochondrial membrane potential of human ovarian cancer cells was assessed upon exposure to propofol combined with cisplatin or doxorubicin. SKOV3 and OVCAR3 cells were treated with different concentrations of propofol (0, 10, 30, and 50 µg/ml) in combination with either 10 µM cisplatin or 1 µM doxorubicin for 24 h. Then, the cells were analyzed using flow cytometry with JC-1 staining. The bars represent the mean ± SD of three independent experiments. Statistical significance is indicated by * for p < 0.05, ** for p < 0.01, and *** for p < 0.001, determined using Student’s t-tests