Table 1. Plasma pharmacokinetic parameters of oxytetracycline following oral administration of 60 mg/kg dose in rainbow trout of different body size at 8 ± 0.5 °C.
| Parameters | Small body size | Medium body size | Large body size |
|---|---|---|---|
| t1/2λz(h) | 85.46 | 87.24 | 86.98 |
| AUC0−last (h*µg/mL) | 82.24 | 108.48 | 144.10 |
| AUC0−∞ (h*µg/mL) | 87.86 | 113.95 | 151.52 |
| AUCextrap (%) | 6.40 | 4.80 | 4.90 |
| MRT0−∞ (h) | 124.73 | 129.36 | 128.97 |
| CL/F (L/h/kg) | 0.68 | 0.53 | 0.40 |
| Vdarea/F (L/kg) | 84.20 | 66.27 | 49.69 |
| Cmax (µg/mL) | 0.66 ± 0.07 | 0.87 ± 0.12 | 1.11 ± 0.12 |
| Tmax (h) | 12.00 | 12.00 | 12.00 |
Notes.
- t1/2λz
- elimination half-life
- AUC
- area under the concentration-versus time curve
- AUCextrap %
- area under the plasma concentration–time curve extrapolated from tlast to ∞ in % of the total AUC
- MRT
- mean residence time
- CL/F
- total body clearance
- Vdarea/F
- apparent volume of distribution
- Cmax
- peak plasma concentration
- Tmax
- time to reach the peak plasma concentration