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Design and synthesis of novel small molecules targeting SMYD3. Reagents and conditions: (A) NH2NH2·H2O, methanol, reflux, 3 h; (B) AcOH, methanol, reflux, 8 h; (C) CH3I, potassium fluoride, acetonitrile, 70°C, 24 h; (D) p‐toluenesulfonic acid, toluene, reflux, 8 h.
