Table 2.
Physician-reported patient characteristics and patient-reported outcomes in patients with ulcerative colitis and bowel urgency by treatment experience.
| Variable | TT-naive (n = 138) |
1L-TT (n = 143) |
TT-exp (n = 83) |
P-value |
|---|---|---|---|---|
| Physician-reported | ||||
| Age, mean (SD) | 37.8 (13.9) | 43.0 (14.5) | 42.7 (13.4) | .004 (t-test) |
| Sex, male, n (%) | 67 (48.6) | 71 (49.7) | 46 (55.4) | .590 (FE) |
| BMI, mean (SD) | 23.2 (3.0) | 24.9 (4.4) | 24.6 (4.5) | .001 (t-test) |
| Smoking status, n | 133 | 136 | 75 | .002 (CH) |
| Current smoker, n (%) | 35 (26.3) | 19 (14.0) | 5 (6.7) | |
| Ex-smoker, n (%) | 45 (33.8) | 51 (37.5) | 24 (32.0) | |
| Never smoked, n (%) | 53 (39.8) | 66 (48.5) | 46 (61.3) | |
| Employment status, n | 137 | 140 | 78 | .152 (CH) |
| Working full-time, n (%) | 68 (49.6) | 72 (51.4) | 43 (55.1) | |
| Working part-time, n (%) | 26 (19.0) | 18 (12.9) | 12 (15.4) | |
| On long-term sick leave, n (%) | 1 (0.7) | 3 (2.1) | 4 (5.1) | |
| Homemaker, n (%) | 9 (6.6) | 13 (9.3) | 7 (9.0) | |
| Student, n (%) | 21 (15.3) | 13 (9.3) | 3 (3.9) | |
| Retired, n (%) | 7 (5.1) | 16 (11.4) | 6 (7.7) | |
| Unemployed, n (%) | 5 (3.6) | 5 (3.6) | 3 (3.8) | |
| Duration of IBD, n | 122 | 131 | 72 | .002 (t-test) |
| Duration of IBD, years, mean (SD) | 4.4 (6.0) | 5.5 (6.0) | 7.5 (5.4) | |
| Current severity, n | 138 | 143 | 83 | .346 (MW) |
| Mild, n (%) | 78 (56.5) | 72 (50.3) | 39 (47.0) | |
| Moderate/severe, n (%) | 60 (43.5) | 71 (49.7) | 44 (53.0) | |
| Current remission status, n | 138 | 143 | 83 | .253 (MW) |
| In remission, n (%) | 42 (30.4) | 41 (28.7) | 17 (20.5) | |
| Current flaring status, n | 129 | 137 | 81 | .032 (FE) |
| Flaring, n (%) | 24 (18.6) | 25 (18.2) | 26 (32.1) | |
| Current steroid use, n | 138 | 143 | 83 | <.001 (FE) |
| Receiving steroids, n (%) | 59 (42.8) | 15 (10.5) | 14 (16.9) | |
| HCP visits, n | 138 | 143 | 83 | .002 (t-test) |
| HCP visits in past year, mean (SD) | 5.0 (4.2) | 7.2 (6.8) | 6.4 (4.1) | |
| Patient-reported | ||||
| EQ VAS, n | 53 | 52 | 24 | .090 (t-test) |
| EQ VAS, mean (SD) | 75.2 (15.5) | 75.8 (16.8) | 67.3 (17.6) | |
| WPAI, n | 32 | 28 | 15 | .214 (t-test) |
| Overall work impairment, mean (SD) % | 33.7 (26.5) | 22.9 (20.5) | 32.1 (26.7) | |
| SIBDQ, n | 51 | 52 | 24 | .341 (t-test) |
| SIBDQ total score, mean (SD) | 50.8 (10.1) | 49.7 (10.7) | 46.8 (14.0) | |
Abbreviations: BMI, body mass index; BU, bowel urgency; CH, χ2 test; EQ VAS, EuroQol visual analog scale; FE, Fisher’s exact test; HCP, healthcare practitioner; IBD, inflammatory bowel disease; MW, Mann–Whitney test; SD, standard deviation; SIBDQ, Short Inflammatory Bowel Disease Questionnaire; TT-naïve, patients who were currently receiving conventional therapy with a duration >3 months and had never received targeted therapy; 1L-TT, patients who were currently receiving their first targeted therapy with a duration >3 months; TT-exp, patients who were currently receiving their second or later targeted therapy with duration >3 months; WPAI, work productivity and activity impairment.