Fig. 10.

Preclinical applications of the convergence of AI and LOs in disease modeling, diagnosis and prediction, as well as drug testing and disease treatment. (A) Computational profiling of hiPSC-derived heart organoids reveals chamber defects associated with NKX2-5 deficiency. Copyright 2022, Springer Nature. (B) Machine learning-assisted neurotoxicity prediction in human midbrain organoids. Copyright 2020, Elsevier Ltd. (C) Machine learning for genetics-based classification and treatment response prediction in cancer of unknown primary. Copyright 2023, Springer Nature [47,203,214].