Table 2.
Multivariable Adjusted Association Between Traditional Risk Factors and All-Cause Mortality Among CAC Consortium and MESA Participants With Very High HDL Cholesterol
| aHR (95% CI) | P Value | |
|---|---|---|
| CAC Consortium (n = 446) | ||
| Age ≥55 y in men, ≥65 y in women | 3.30 (1.30-8.40) | 0.01 |
| Woman | 1.64 (0.58-4.61) | 0.35 |
| Non-White race | 2.01 (0.85-4.75) | 0.11 |
| Current cigarette smoking | 0.61 (0.08-4.62) | 0.63 |
| Family history of CHD | 0.55 (0.21-1.47) | 0.23 |
| Obesity | 2.17 (0.58-8.09) | 0.25 |
| Hypertension | 1.54 (0.66-3.59) | 0.32 |
| LDL-C ≥130 mg/dLa | 1.03 (0.44-2.45) | 0.94 |
| HDL-C, per SD higherb | 1.12 (0.73-1.72) | 0.61 |
| Diabetes | 2.56 (0.69-9.55) | 0.16 |
| MESA (n = 119) | ||
| Age ≥55 y in men, ≥65 y in women | 2.33 (0.96-5.66) | 0.06 |
| Woman | 0.32 (0.14-0.74) | 0.008 |
| Race/ethnicity | ||
| White | Ref | - |
| Chinese | 0.47 (0.11-2.03) | 0.31 |
| Black | 0.78 (0.41-1.49) | 0.45 |
| Hispanic | 2.91 (0.96-8.80) | 0.06 |
| Current cigarette smoking | 0.80 (0.27-2.39) | 0.68 |
| Family history of CHD | 1.04 (0.54-2.02) | 0.90 |
| Obesity | 0.56 (0.22-1.40) | 0.21 |
| Hypertension | 1.46 (0.77-2.78) | 0.25 |
| LDL-C ≥130 mg/dLa | 0.73 (0.33-1.63) | 0.44 |
| HDL-C, per SD higherb | 0.80 (0.51-1.24) | 0.32 |
| Diabetes | 2.56 (0.86-7.66) | 0.09 |
aHR = adjusted hazard ratio; other abbreviations as in Table 1.
a
Also includes all individuals on lipid-lowering therapy.
b
13 mg/dL in CAC Consortium, 14 mg/dL in MESA.