Table 4.

Unadjusted and adjusted factors associated with liver-related mortality among people with an HCV notification.

Characteristics	Liver-related mortality n (%)	IRR	95% CI	p	aIRR	95% CI	p
Year of birtha
≥1967	642 (1)	1.00	–	–	1.00	–	–
<1967	4167 (8)	7.24	6.66–7.86	<0.001	7.14	6.56–7.77	<0.001
Sex
Female	1185 (3)	1.00	–	–	1.00	–	–
Male	3624 (5)	1.71	1.60–1.82	<0.001	1.36	1.27–1.45	<0.001
HBV co-infection
No	4522 (4)	1.00	–	–	1.00	–	–
Yes	287 (7)	1.57	1.41–1.77	<0.001	1.40	1.24–1.58	<0.001
History of AUD
No	2125 (2)	1.00	–	–	1.00	–	–
Yes	2684 (11)	4.62	4.37–4.88	<0.001	5.01	4.72–5.31	<0.001
Charlson comorbidity index 3+b
No	4239 (4)	1.00	–	–	1.00	–	–
Yes	570 (9)	2.47	2.31–2.65	<0.001	1.39	1.28–1.53	<0.001
Elimination erac
No	4549 (5)	1.00	–	–	1.00	–	–
Yes	260 (1)	0.24	0.21–0.27	<0.001	0.38	0.33–0.43	<0.001

Unadjusted and adjusted factors associated with liver-related mortality among people with an HCV notification. Data from people with an HCV notification (n = 112,277) in New South Wales, 1995–2022.

Factors associated with liver-related mortality were evaluated using unadjusted and adjusted Poisson regression analyses. The adjusted model is based on 111,782 individuals. aIRR, adjusted incidence rate ratio; HBV, hepatitis C virus; IRR, incidence rate ratio; AUD, Alcohol use disorder.

^aStratified around median.

^bCharlson comorbidity index score is an indicator of health; higher scores indicate worse health condition.

^cElimination Era: Post 1 January 2015.