Table 3.
Sensitivity and specificity of the diagnostic criteria for CIM.
| CIM− (n = 10) |
CIM+ (n = 12) |
Sensitivity for CIM diagnosis | Specificity for CIM diagnosis | ||
|---|---|---|---|---|---|
| Clinical criteria | (1) Critical illness | 10/10, 100 % | 12/12, 100 % | − | − |
| (2) Clinical weakness | 8/10, 80 % | 12/12, 100 % | 100 % | 20 % | |
| electrophysiological criteria | (3–6) Combined | 0/10, 0 % | 12/12, 100 % | 100 % | 100 % |
| (3 & 4) NCS | 0/10, 0 % | 12/12, 100 % | 100 % | 100 % | |
| (5) EMG/Inexcitability | 3/10, 30 % | 12/12, 100 % | 100 % | 70 % | |
| (6) Repetitive Stimulation | 0/10, 0 % | 0/12, 0 % | − | − | |
| Muscle biopsy | (7) M:A ratio | 0.88 (±0.35) | 0.66 (±0.19) | 33 % | 50 % |
Note. Data are reported as mean (±standard deviation) or absolute numbers (percentages). The diagnostic criteria for CIM are divided into clinical and electrophysiological criteria, and muscle biopsy. See Latronico and Bolton (2011) for a detailed description of the individual criteria. CIM, critical illness myopathy; NCS, nerve conduction studies; EMG, electromyography; M:A ratio, myosin:actin ratio.