Table 2.
Echocardiographic analysis of left ventricular function and structure in WT and SCD4−/− mice
| Parameter | WT Chow | WT HFD | SCD4−/− Chow | SCD4−/− HFD |
|---|---|---|---|---|
| HR [bpm] | 361 ± 18 | 333 ± 39 | 336 ± 50 | 345 ± 38 |
| AWTd [mm] | 0.83 ± 0.03 | 0.91 ± 0.06 | 0.87 ± 0.09 | 0.91 ± 0.09 |
| PWTd [mm] | 0.91 ± 0.05 | 1.03 ± 0.05 | 0.95 ± 0.07 | 1.04 ± 0.12 |
| EDD [mm] | 4.10 ± 0.12 | 3.73 ± 0.17a | 3.66 ± 0.21a | 3.67 ± 0.36a |
| ESD [mm] | 2.72 ± 0.14 | 2.53 ± 0.16a | 2.27 ± 0.33a | 2.28 ± 0.24a |
| RWT | 0.44 ± 0.02 | 0.55 ± 0.01a | 0.52 ± 0.04 | 0.57 ± 0.09a |
| EF [%] | 70.67 ± 1.51 | 68.67 ± 1.37 | 75.00 ± 11.24 | 75.67 ± 2.73 |
| CO [mL/min] | 17.75 ± 1.23 | 12.64 ± 2.86 | 12.91 ± 2.82 | 13.81 ± 4.20 |
AWTd, anterior wall thickness in diastole; CO, cardiac output; EDD, end-diastole diameter; EF, ejection fraction; ESD, end-systole diameter; HR, heart rate; PWTd, posterior wall thickness in diastole; RWT, relative wall thickness. The data are expressed as mean ± SD, n = 5–6 mice/group.
a
P < 0.05, versus WT chow.