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. 2024 May 2;31(9):1377–1385. doi: 10.1038/s41594-024-01299-2

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 8 — (a) Intermediate states of the S6 helices. Steric clashes preventing full opening of the S6 helix are shown as pink triangles. Angles of opening are shown as a measure of the intermediate state. For LPAx3, the S6-C helix is distorted from a typical α-helical structure. (b) Steric clash between the superimposed position of Y511 in the closed state (grey) and L574 in the LPAx4 state (magenta) shows that the inward movement of Y511 is necessary for open transitions to occur. Boxed figure shows a zoom-in of the steric clash represented as pink pseudobonds (<2.5 Å distance). (c) Proposed mechanism for the LPA-induced opening of TRPV1 as the channel goes from apo state (grey) to one completely occupied by LPA (magenta). Residues in contact with M682 (< 5.0 Å) as it switches positions with L681 due to the π-α helix transition are highlighted. 1. M682 maintains contact with several hydrophobic residues in the apo state. 2. The S4-S5 linker moves inward toward the pocket because of Y511 flipping toward the pocket with LPA bound; the space around M682 opens. 3. S5 and S6 dilate away from the pore axis because of the void created by the moving of the S4-S5 linker; M682 is able to rotate towards the pore axis and the π-α transition occurs.