TABLE 1.

Abnormal glycosylation modifications in SCZ.

	Tissue		Sample size			Changes in glycosylation	References
	Category	Type	N	Individuals with SCZ	Healthy controls
N-glycosylation	Brain (Autopsy)	DLPFC	67	35	31	GluA2 subunit (Man↓)	Tucholski et al. (2013a)
	Brain (Autopsy)	DLPFC	67	35	31	GluK2 subunit (Man↑) (Hybridization↓)	Tucholski et al. (2013b)
	Blood	Serum	51	17	34	GluK2/3 (N-glycosylation↓)	Ambalavanan et al. (2016)
	Brain (Autopsy)	Anterior cingulate cortex; DLPFC	68	35	33	EAAT1 ↓ EAAT2 ↓	Bauer et al. (2010)
	Brain (Autopsy)	STG	28	14	14	GABAAR β2 subunit (N-glycosylation↑)	Mueller et al. (2014)
	Cell	STG isolates subcellular	30	16	14	GABAAR β2 subunit↑	Mueller et al. (2015)
O-glycosylation	Brain (Autopsy)	STG	20	10	10	GALNT16↓	Mueller et al. (2019a)
	Brain (Autopsy)	STG	34	17	17	O-GalNaAc↓; O-GlcNAcylation↑	Mueller et al. (2018a)
Glycosyltransferases	Brain (Autopsy)	DLPFC	24	12	12	UGGT2↑	Kim et al. (2018)
	Brain (Autopsy)	DLPFC	24	12	12	B3GNT8↓; MGAT4A↓	Kippe et al. (2015)
	Brain (Autopsy)	STG	30	16	14	POFUT2↑; FUT8↓	Mueller et al. (2017)
PSA-NCAM	Brain (Autopsy)	Hippocampus	36	21	21	PSA↓; Protein adhesive↓	Vawter et al. (2001)
	Blood	Serum	106	55	51	PSA↑; Hippocampal gray matter volume↓	Müller-Miny et al. (2023)
	Blood; Brain	Serum; Hippocampus	88	44	44	PSA-NCAM↑ brain integrity↓	An et al. (2020)
	ST8SIA2 knockout mice	Hippocampus	Unknow	8	Unknow	ST8SIA2↓	Kröcher et al. (2015)
	Brain (Autopsy)	STG	30	16	14	ST8SIA2↑	Mueller et al. (2018b)