Table 1.
Patient characteristics of the study cohort based on biochemical variables measured in serum samples.
| Lipoprotein(a) decile | N | Patient Characteristics |
|||
|---|---|---|---|---|---|
| ≤70th, N = 132,092 | 70th - 80th, N = 18,400 | 80th - 90th, N = 17,872 | ≥90th, N = 16,566 | ||
| Lipoprotein(a) mg/dL | 184,930 | 10 (6, 15) | 39 (34, 44) | 62 (56, 69) | 90 (85, 112) |
| Sex | 184,930 | ||||
| Men | 69,910 (53 %) | 9,102 (49 %) | 9,348 (52 %) | 8,495 (51 %) | |
| Women | 62,182 (47 %) | 9,298 (51 %) | 8,524 (48 %) | 8,071 (49 %) | |
| Age, years | 184,930 | 39 (31, 45) | 39 (31, 45) | 39 (31, 45) | 40 (32, 45) |
| Triglycerides mmol/L | 111,417 | 1.21 (0.84, 1.85) | 1.17 (0.83, 1.75) | 1.20 (0.84, 1.78) | 1.23 (0.88, 1.82) |
| Cholesterol mmol/L | 173,580 | 5.10 (4.40, 5.90) | 5.20 (4.50, 6.00) | 5.30 (4.60, 6.00) | 5.60 (4.90, 6.40) |
| LDL-C mmol/L | 163,275 | 3.18 (2.55, 3.90) | 3.27 (2.64, 3.99) | 3.36 (2.74, 4.05) | 3.61 (2.96, 4.32) |
| LDL-C-corr mmol/L | 163,275 | 3.09 (2.46, 3.81) | 2.98 (2.36, 3.70) | 2.89 (2.29, 3.60) | 2.83 (2.19, 3.55) |
| HDL-C mmol/L | 173,383 | 1.31 (1.09, 1.59) | 1.31 (1.09, 1.60) | 1.32 (1.10, 1.60) | 1.34 (1.13, 1.61) |
| Apolipoprotein A1 g/L | 33,759 | 1.50 (1.35, 1.67) | 1.50 (1.35, 1.68) | 1.50 (1.35, 1.69) | 1.54 (1.39, 1.71) |
| Apolipoprotein B g/L | 33,878 | 1.00 (0.83, 1.19) | 1.03 (0.87, 1.23) | 1.08 (0.91, 1.27) | 1.18 (1.00, 1.37) |
| HbA1c % | 52,899 | 5.30 (5.10, 5.60) | 5.30 (5.10, 5.60) | 5.30 (5.10, 5.60) | 5.35 (5.10, 5.60) |
| Glucose mmol/L | 54,475 | 5.00 (4.60, 5.40) | 4.90 (4.60, 5.30) | 4.90 (4.60, 5.30) | 5.00 (4.60, 5.40) |
| Creatinine µmol/L | 141,029 | 75 (65, 85) | 75 (65, 86) | 76 (66, 86) | 76 (66, 87) |
| eGFR mL/min/1.73m2 | 141,029 | 78 (61, 93) | 74 (60, 92) | 78 (61, 93) | 76 (61, 93) |
| TSH mU/L | 136,206 | 1.47 (1.04, 2.04) | 1.46 (1.03, 2.05) | 1.48 (1.06, 2.04) | 1.47 (1.06, 2.05) |
| Aspartate aminotransferase U/L | 97,737 | 22 (18, 28) | 22 (18, 28) | 22 (18, 28) | 23 (18, 28) |
| Alanine aminotransferase U/L | 132,770 | 25 (18, 37) | 24 (18, 36) | 25 (18, 36) | 25 (18, 36) |
| Gamma-glutamyl transferase U/L | 95,701 | 21 (14, 35) | 20 (14, 34) | 21 (14, 34) | 22 (15, 36) |
| Vitamin D nmol/L | 57,659 | 62 (44, 80) | 58 (40, 77) | 61 (44, 81) | 62 (45, 80) |
| Vitamin B12 pmol/L | 108,926 | 304 (247, 380) | 307 (248, 386) | 306 (248, 382) | 309 (250, 383) |
| Folate nmol/L | 80,919 | 14 (10, 20) | 14 (10, 20) | 14 (10, 20) | 14 (10, 20) |
| Homocysteine µmol/L | 43,186 | 10.4 (8.4, 12.9) | 10.2 (8.2, 12.6) | 10.3 (8.3, 12.7) | 10.3 (8.3, 12.8) |
| Methylmalonic acid µmol/L | 21,544 | 0.15 (0.12, 0.18) | 0.14 (0.11, 0.18) | 0.14 (0.12, 0.18) | 0.15 (0.12, 0.19) |
| C-reactive protein high sensitivity mg/L | 31,172 | 1.0 (1.0, 3.0) | 1.0 (1.0, 3.0) | 1.0 (1.0, 3.0) | 1.0 (1.0, 3.0) |
| Sedimentation rate mm | 6,461 | 4 (2, 8) | 4 (2, 10) | 5 (2, 10) | 4 (1, 10) |
| Carbohydrate deficient transferrin % | 4,902 | 0.80 (0.60, 1.20) | 0.80 (0.70, 1.50) | 0.80 (0.60, 1.30) | 0.90 (0.70, 1.60) |
| Phosphatidylethanol µmol/L | 232 | 0.11 (0.02, 0.40) | 0.09 (0.00, 0.20) | 0.24 (0.02, 0.41) | 0.18 (0.02, 0.75) |
Median (IQR); n (%).
Phosphatidylethanol, HbA1c and sedimentation rate was measured in whole blood, and homocysteine was measured in plasma. The first Lp(a) measurement in each individual between 2000-2019 was included. Creatinine measurements were traceable to isotope dilution mass spectrometry (IDMS). eGFR was calculated from the 2009 CKD-EPI equation. Glucose was tested while fasting. LDL-C = low-density lipoprotein cholesterol; LDL-C-corr = low-density lipoprotein cholesterol corrected; HDL-C = high-density lipoprotein cholesterol; HbA1c = haemoglobin A1c; eGFR = estimated glomerular filtration rate; TSH = thyroid stimulating hormone; IQR = interquartile range.