Fig. 4.
Cell-state specific responses to DT treatment. a) MAPK activity score (assessed using the expression of common genes in two MAPK pathway gene sets25,26) in DMSO control (blue) and DT-treated (orange) differentiated, neural crest-like and undifferentiated cells. Data comparison performed using the linear mixed effect model. b) Proportion of responding (teal) and nonresponding (red) cells in each patient's DT-treated tumour samples, arranged by cell state. c) Gene set enrichment analysis of the Hallmark signatures in responding and nonresponding melanoma cells in DT-treated samples, analysed using edgeR. Comparison separated by cell state and normalized enrichment score (NES) and p values shown. d) Expression of the Hallmark IL6 and TNFA signalling gene sets in responding (teal) and nonresponding (red) melanoma cells categorized by cell state. Data comparison performed using the linear mixed effect model.