Table 1.
Patient characteristics and group differences before starting kidney replacement therapy
| Characteristics | All patients (N = 695) |
Any KRT (n = 342) |
Dialysis (n = 200) |
Preemptive Tx (n = 142) |
|---|---|---|---|---|
| Age (yr) | 12.3 (5.6) | 14.4 (4.1) | 14.5 (4.3) | 14.2 (3.5) |
| Female sex | 243 (35%) | 122 (35.7%) | 78 (39%) | 44 (31%) |
| Primary renal diagnosis | ||||
| CAKUT | 477 (68.6%) | 212 (61.8%) | 119 (59.5%) | 93 (65.5%) |
| Glomerulopathy | 59 (8.5%) | 35 (10.2%) | 28 (14%) | 7 (4.9%) |
| Post-AKI CKD | 34 (4.9%) | 17 (5%) | 9 (4.5%) | 8 (5.6%) |
| Tubulointerstitial disease | 94 (13.5%) | 61 (17.8%) | 33 (16.5%) | 28 (19.7%) |
| Other/unknown | 31 (4.5%) | 17 (5%) | 11 (5.5%) | 6 (4.2%) |
| Comorbidities | ||||
| 0 | 321 (46.2%) | 138 (40.4%) | 75 (37.5%) | 63 (44.4%) |
| ≥1 | 374 (53.8%) | 204 (59.5%) | 125 (62.5%) | 76 (53.5%) |
| Physical activity | ||||
| none | 157 (23.1%) | 114 (33.2%) | 68 (34%) | 46 (32.4%) |
| 1–4 h/wk | 241 (35.5%) | 110 (32.1%) | 60 (30%) | 50 (35.2%) |
| >4 h/wk | 281 (41.4%) | 104 (30.4%) | 63 (31.5%) | 41 (28.9%) |
| BMI SDS | 0.19 (1.55) | 0.19 (1.56) | 0.19 (1.6) | 0.18 (1.49) |
| Height SDS | −1.24 (1.63) | −1.22 (1.85) | −1.44 (2.14) | −0.96 (1.63) |
| Δ height SDS/yr | — | −0.043 (0.51) | −0.051 (0.6) | −0.038 (0.41) |
| Systolic blood pressure SDS | 0.71 (1.63) | 0.95 (1.63) | 0.95 (1.64) | 0.94 (1.68) |
| Δ systolic blood pressure SDS/yr | — | 0.324 (3.19) | 0.107 (3.13) | 0.56 (3.01) |
| Diastolic blood pressure SDS | 0.58 (1.27) | 0.69 (1.46) | 0.77 (1.61) | 0.66 (1.27) |
| Δ diastolic blood pressure SDS/yr | — | 0.004 (2.45) | 0.113 (2.29) | −0.02 |
| No. of antihypertensive drugs | 1 (1) | 1 (2) | 1 (2) | 1 (1) |
| eGFR (ml/min per 1.73 m2) | 25.6 (16.8) | 11.6 (5.1) | 11.8 (5.2) | 11.1 (5.1) |
| Δ eGFR (ml/min per 1.73m2/yr) | — | −5.0 (8.6) | −5.5 (8.9) | −4.8 (7.7) |
| Hemoglobin (g/dl) | 11.7 (2.2) | 10.9 (1.8) | 10.8 (1.9) | 11.1 (1.9) |
| Serum urea (g/dl) | 43.9 (26.5) | 74 (49.3) | 76.1 (47.6) | 72.8 (53.8) |
| Serum bicarbonate (mmol/l) | 21.3 (4.6) | 21.2 (4.8) | 21 (5.13) | 21.4 (4.6) |
| Serum calcium (mmol/l) | 2.27 (0.21) | 2.33 (0.34) | 2.29 (0.3) | 2.38 (0.35) |
| Serum phosphorus (mmol/l) | 1.5 (0.36) | 1.73 (0.5) | 1.78 (0.54) | 1.7 (0.42) |
| Serum iPTH (pmol/l) | 13.5 (16.5) | 24.4 (36.5) | 26.8 (36) | 18.7 (27.2) |
| Serum potassium (mmol/l) | 4.5 (0.8) | 4.5 (1) | 4.5 (0.9) | 4.5 (0.9) |
CAKUT, congenital anomalies of the kidney and urinary tract; eGFR, estimated glomerular filtration rate; iPTH, intact parathyroid hormone; KRT, kidney replacement therapy; post-AKI CKD, post-acute kidney injury chronic kidney disease; SDS, SD score; Tx, kidney transplant.
Data were obtained at study entry (first column) and at the last visit before start of KRT (columns 2–4).
Data represent absolute numbers (%), median (interquartile range).
Δ annualized change in variables calculated from 2 last measurements before KRT.