Table 2.
Factors associated with start of kidney replacement therapy
| Variables | Any KRT |
Dialysis |
Preemptive Tx |
|||
|---|---|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | |
| eGFR (ml/min per 1.73 m2) | 0.76 (0.74–0.78) | <0.001 | 0.77 (0.74–0.8) | <0.001 | 0.74 (0.71–0.77) | <0.001 |
| eGFR slope (ml/min per 1.73 m2 per yr) | 0.90 (0.85–0.95) | <0.001 | 0.89 (0.83–0.96) | <0.001 | 0.93 (0.84–1.0) | 0.14 |
| Primary renal diagnosis (reference: CAKUT) | ||||||
| Glomerulopathy | 3.80 (2.51–5.75) | <0.001 | 5.39 (3.29–8.82) | <0.001 | 1.9 (0.83–4.38) | 0.13 |
| Tubulointerstitial | 1.56 (1.14–2.14) | 0.006 | 1.44 (0.94–2.20) | 0.09 | 1.79 (1.11–2.88) | 0.02 |
| Post-AKI CKD | 1.69 (0.94–3.03) | 0.08 | 1.32 (0.61–2.86) | 0.48 | 2.28 (0.95–5.49) | 0.07 |
| others/unknown | 1.56 (0.85–2.86) | 0.16 | 1.66 (0.76–3.6) | 0.2 | 1.56 (0.59–4.14) | 0.37 |
| Comorbidities ≥ 1 vs. none | 1.21 (0.913–1.6) | 0.185 | 1.54 (1.05–2.24) | 0.026 | 0.89 (0.587–1.35) | 0.586 |
| Age (reference: 6 to 9 yr) | ||||||
| >9–12 yr | 1.1 (0.66–1.83) | 0.721 | 1.31 (0.67–2.57) | 0.426 | 0.846 (0.38–1.89) | 0.683 |
| >12–14 yr | 1.96 (1.19–3.22) | 0.008 | 2.19 (1.13–4.23) | 0.019 | 1.72 (0.806–3.68) | 0.161 |
| >14–16 yr | 1.7 (1.03–2.81) | 0.038 | 1.77 (0.90–3.49) | 0.1 | 1.58 (0.74–3.36) | 0.233 |
| >16 yr | 1.2 (0.728–1.97) | 0.479 | 1.72 (0.90–3.29) | 0.099 | 0.69 (0.313–1.51) | 0.353 |
| BMI SDS | 0.77 (0.66–0.9) | 0.001 | 0.73 (0.60–0.89) | 0.002 | 0.82 (0.63–1.07) | 0.151 |
| Systolic blood pressure SDS (reference: −2 to 0) | ||||||
| <−2 | 1.85 (0.769–4.44) | 0.17 | 1.53 (0.45–5.19) | 0.495 | 2.39 (0.67–8.5) | 0.178 |
| >0–1 | 1.62 (1.16–2.26) | 0.005 | 1.83 (1.18–2.86) | 0.007 | 1.34 (0.81–2.23) | 0.258 |
| >1 | 2.07 (1.49–2.87) | <0.001 | 2.15 (1.38–3.34) | <0.001 | 2.02 (1.23–3.32) | 0.005 |
| Hemoglobin (g/dl) | 0.88 (0.81–0.96) | 0.003 | 0.8 (0.72–0.9) | <0.001 | 1.00 (0.88–1.13) | 0.954 |
| Serum bicarbonate (mmol/l) | 1.07 (0.998–1.14) | 0.057 | 1.1 (1.01–1.21) | 0.03 | 1.02 (0.91–1.14) | 0.72 |
BMI, body mass index; CAKUT, congenital anomalies of the kidney and urinary tract; CI, confidence interval; eGFR, estimated glomerular filtration rate; HR, hazard ratio; KRT, kidney replacement therapy; post-AKI CKD, post-acute kidney injury chronic kidney disease; SDS, SD score; Tx kidney transplant.
Linear competing risk analysis. Only significant variables are shown. For some variables, correlation was linear only in definite ranges: eGFR ≤25 ml/min per 1.73 m2; BMI SDS ≤0; serum bicarbonate ≥22 mmol/l.