Table 1.
Comparison of baseline pre-TAVR and postprocedural characteristics of patients with and without HDAVB
| Variable | All patients N = 121 |
No HDAVB n = 109 |
HDAVB n = 12 |
p value |
|---|---|---|---|---|
| Age, y | 79 (73-85) | 79 (73-85) | 76 (70-81) | 0.33 |
| Male | 65 (54%) | 60 (55%) | 5 (42%) | 0.38 |
| BMI, kg/m2 | 29 (25-32) | 28 (29-32) | 30 (27-36) | 0.35 |
| Comorbidities | ||||
| Atrial fibrillation/flutter | 42 (35%) | 39 (36%) | 3 (25%) | 0.46 |
| Cerebrovascular disease | 8 (7%) | 7 (6%) | 1 (8%) | 0.80 |
| Coronary artery disease | 58 (48%) | 56 (51%) | 2 (17%) | 0.02 |
| Diabetes mellitus | 42 (35%) | 38 (35%) | 4 (33%) | 0.92 |
| Hypertension | 101 (8%) | 94 (86%) | 7 (58%) | 0.01 |
| STS score | 17 (12-25) | 17 (13-25) | 11 (9-20) | 0.23 |
| Imaging | ||||
| LVEF, % | 60 (53-68) | 60 (53-68) | 59 (55-66) | 0.98 |
| LVEF <50% | 26 (22%) | 24 (22%) | 2 (17%) | 0.67 |
| LVOT area, mm2 | 469 (368-559) | 447 (374-559) | 475 (362-559) | 0.84 |
| Annular area, mm2 | 469 (398-540) | 462 (398-540) | 469 (394-581) | 0.68 |
| EP Pre-OP ECG/EP studies | ||||
| Rhythm | ||||
| Sinus | 100 (83%) | 89 (82%) | 11 (92%) | 0.39 |
| Atrial fibrillation | 21 (17%) | 20 (18%) | 1 (8%) | |
| PR, ms | 189 (168-215) | 190 (168-213) | 185 (164-223) | 0.89 |
| PRE PRS ≥220 ms | 25 (25%) | 21 (23%) | 4 (36%) | 0.35 |
| QRS duration, ms | 106 (91-129) | 106 (91-120) | 136 (84-150) | 0.07 |
| Right bundle branch block | 22 (18%) | 14 (13%) | 8 (67%) | <0.01 |
| Left bundle branch block | 9 (7%) | 9 (8%) | 0 (0%) | 0.30 |
| AH interval, ms | 101 (80-123) | 100 (80-121) | 101 (87-160) | 0.53 |
| HV interval, ms | 52 (45-58) | 52 (45-59) | 50 (46-54) | 0.44 |
| Pre-TAVR EP studies HV ≥65 ms | 10 (8%) | 10 (9%) | 0 (0%) | 0.27 |
| TAVR | ||||
| Implant depth, mm | 4 (4-6) | 4 (4-6) | 6 (4-8) | 0.02 |
| Implant depth ≤4mm | 85 (70%) | 80 (73%) | 5 (42%) | 0.03 |
| Implant depth >4 mm | 36 (30%) | 29 (26%) | 7 (59%) | |
| Percent over/undersized | 5 (1-11) | 5 (1-10) | 8 (−1-20) | 0.09 |
| Type of valve | ||||
| Balloon expandable valve (Sapien) | 109 (90%) | 101 (93%) | 8 (67%) | <0.01∗ |
| Mechanically-expanding valve (Lotus) | 2 (2%) | 1 (1%) | 1 (8%) | |
| Self-expanding valve (Evolut) | 10 (8%) | 7 (6%) | 3 (25%) | |
| Valve-in-valve replacement | 9 (7%) | 9 (8%) | 0 (0%) | 0.30 |
Abbreviations: BMI, body mass index; ECG, electrocardiogram; EP, electrophysiology; HDAVB, high-degree atrioventricular block; HV, His-ventricular; LVEF, left ventricular ejection fraction; LVOT, left ventricular outflow tract; STS, Society of Thoracic Surgeons score; TAVR, transcatheter aortic valve replacement.
∗
Balloon expandable valve (Sapien) as a reference.