Table 1.
Demographic characteristics and clinical data: total cohort
| Variable | Total patients (N = 297) | Early-start peritoneal dialysis (n = 130) | Conventional-start peritoneal dialysis (n = 167) | P value |
|---|---|---|---|---|
| Age (yr, [SD]) | 58.7 ± 16.5 | 56.6 ± 17.3 | 60.3 ± 15.7 | 0.049 |
| Sex (male, n, %) | 208 (70.0%) | 90 (69.2%) | 118 (70.7%) | 0.8 |
| Primary kidney disease (n, %) | 0.5 | |||
| Diabetic nephropathy | 128 (43.1%) | 60 (46.2%) | 68 (40.7%) | |
| Hypertension | 41 (13.8%) | 15 (11.5%) | 26 (15.6%) | |
| Polycystic kidney disease | 12 (4.0%) | 3 (2.3%) | 9 (5.4%) | |
| Glomerulonephritis | 70 (23.6%) | 30 (23.1%) | 40 (24.0%) | |
| Other | 46 (15.5%) | 22 (16.9%) | 24 (14.4%) | |
| Obesity (n, %) | 85 (28.6%) | 35 (26.9%) | 50 (29.9%) | 0.3 |
| Body mass index (n, [SD]) | 27.4 ± 6.0 | 26.9 ± 5.8 | 27.8 ± 6.2 | 0.2 |
| Late referral to nephrologist (n, %) | 14 (4.7%) | 8 (6.2%) | 6 (3.6%) | 0.3 |
| Indication for dialysis commencement (n, %) | 0.06 | |||
| Mild uremia | 233 (78.5%) | 95 (73.1%) | 138 (82.6%) | 0.047a |
| Fluid overload | 34 (11.4%) | 15 (11.5%) | 19 (11.4%) | 0.97 |
| Hyperkalemia | 21 (7.1%) | 14 (10.8%) | 7 (4.2%) | 0.03a |
| Uremic encephalopathy or pericarditis | 3 (1.0%) | 3 (2.3%) | 0 (0.0%) | 0.048a |
| Metabolic acidosis | 6 (2.0%) | 3 (2.3%) | 3 (1.8%) | 0.8 |
| Antiplatelet or anticoagulant therapy (n, %) | 0.2 | |||
| No | 190 (64.0%) | 88 (67.7%) | 102 (61.1%) | |
| Single antiplatelet | 68 (22.9%) | 27 (20.8%) | 41 (24.6%) | |
| Dual antiplatelet | 11 (3.7%) | 7 (5.4%) | 4 (2.4%) | |
| Anticoagulation | 20 (6.7%) | 6 (4.6%) | 14 (8.4%) | |
| Anticoagulation and antiplatelet | 8 (2.7%) | 2 (1.5%) | 6 (3.6%) | |
| Technique for peritoneal dialysis (PD) catheter insertion (n, %) | <0.001 | |||
| Laparoscopic | 194 (65.3%) | 63 (48.5%) | 131 (78.4%) | <0.001 |
| Modified Seldinger | 103 (34.7%) | 67 (51.5%) | 36 (21.6%) | <0.001 |
| Estimated glomerular filtration rate at commencement (ml/min per 1.73 m2, [SD]) | 7.4 ± 2.9 | 6.8 ± 3.0 | 7.8 ± 2.9 | 0.002 |
| Serum creatinine at commencement (μmol/l, [SD]) | 696.3 ± 288.0 | 771.7 ± 323.2 | 636.9 ± 241.8 | <0.001 |
| Inpatient admission | 103 (34.7%) | 55 (42.3%) | 48 (28.7%) | 0.02 |
| Hospital length of stay (d [median], range) | 1.0 (0–52) | 1.0 (0–48) | 1.0 (0–52) | 0.7 |
| Time to PD commencement (d [median], [SD]) | 18.0 ± 15.3 | 11.0 ± 4.3 | 26.0 ± 14.2 | <0.001 |
| Bridging hemodialysis prior to PD (n, %) | 65 (22.0%) | 31 (23.8%) | 34 (20.5%) | 0.5 |
| Follow-up time (d [mean], [SD]) | 845.5 ± 305.3 | 821.9 ± 282.4 | 863.8 ± 321.6 | 0.2 |
PD, peritoneal dialysis.
Demographic characteristics and clinical data of patients undertaking early-start and conventional-start PD. Early-start PD patients were younger, more likely to receive a catheter inserted using the modified Seldinger technique, had worse renal function at time of dialysis commencement, and were more likely to require a post-procedural inpatient admission.
a
Non-significant result after accounting for Bonferroni correction due to making multiple comparisons.