Figure 3.

Comodulation at mid concentrations reduces the interindividual variability of pyloric rhythm parameters on the circuit output level. A, Circular plot of a randomly generated phase dataset (N = 10; $\overline{x}$ = 0.35; µ = 0.15). The length of the r-vector indicates the spread of the data. We use 1 − r as measure for variability of circular data. Markers inside the circle indicate 25, 50, and 75% of the radius of the unit circle. B, Burst start (on) and termination (off) and the corresponding circular variance (1 − r; see Materials and Methods) under different modulatory conditions (color coded). Individual dots represent data from individual experiments; red bars indicate the circular mean. Asterisks indicate pairwise significant differences between the group indicated with the longer line and those indicated with shorter lines. All other pairwise comparisons were not statistically significant. N = 15 animals. Statistical results are shown in Table 1. Total modulator concentration for [low]: 10⁻⁹ M; [mid]: 3 × 10⁻⁸ M. C, Sum of eigenvalues from the covariance matrix of the phases shown in panel B for each modulatory condition.