Figure 4.

Comodulation at mid concentrations reduces the interindividual variability of burst parameters on the circuit output level. A, Average number of spikes (#spks) per burst and corresponding CV for each type of neuron at each modulatory condition (color coded). B, Average spike frequency (F_spks) within a burst and corresponding CV for each type of neuron at each modulatory condition (color coded). C, Sum of eigenvalues from the covariance matrix of pooled #spks and F_spks for each modulatory condition. Asterisks indicate pairwise significant differences between the group indicated with the longer line and those indicated with shorter lines. The two groups indicated with daggers in panel A are significantly different from all other groups but not one another. All other pairwise comparisons were not statistically significant. N = 15 animals. Dots represent values from individual experiments; horizontal bars indicate the mean values. Statistical results in Table 1. Total modulator concentration for [low]: 10⁻⁹ M; [mid]: 3 × 10⁻⁸ M.