Figure 7.

Comodulation does not reduce the interindividual variability of rebound from periodic inhibition on the single cell level. A, One example of LP membrane potential in response to periodic hyperpolarization. B, One example periodic rebound experiment in different modulatory conditions (color coded). The top panels show the spike raster plots for all 20 sweeps. The bottom panels show the intracellular voltage of all sweeps. t₀ indicates the time point when LP was released from current injection. C, Spike histogram across the last 10 sweeps in different modulatory conditions. D, Sigmoid fits to the cumulative spike histograms. Dots indicate the sigmoid midpoint. E, Latency and fit parameters (#spks = a, slope factor = k in Eq. 2) with the corresponding metric of variability (CV, or SD for interval data) for different modulatory conditions (color coded). Dots represent values from individual experiments; horizontal bars indicate the means. N = 19, except PCR N = 11. Statistical results in Table 6 indicate no significant difference between the means of the groups. Total modulator concentration for [mid]: 1–3 × 10⁻⁸ M for P and PC, 3 × 10⁻⁸ M for PCR.