Table 1.
Comparison of biological data between NHPT and HPHPT groups
| N | Whole population | NHPT | HPHPT | P | |
|---|---|---|---|---|---|
| Calcium diet (mg/day) | 91 | 516 (286-696) | 527 (284-696) | 466 (305-689) | .1 |
| Parathyroid gland weight (mg) | 45 | 400 (200-1045) | 273 (127-700) | 500 (260-1250) | .05 |
| Serum creatinine (µmol/L) | 91 | 66 (55-79) | 60 (51-80) | 67 (58-77) | .42 |
| eGFRa (mL/min/1.73 m2) | 91 | 95.5 (86-106) | 95.5 (83-105) | 95.4 (87-107) | .32 |
| Preload iCa (1.14 < N < 1.31 mmol/L) | 91 | 1.33 (1.29-1.41) | 1.28 (1.25-1.29) | 1.38 (1.35-1.43) | <.0001 |
| Postload iCa (1.14 < N < 1.31 mmol/L) | 91 | 1.43 (1.37-1.49) | 1.37 (1.34-1.40) | 1.48 (1.43-1.54) | <.0001 |
| Preload calcemia (2.20 < N < 2.51 mmol/L) | 91 | 2.58 (2.47-2.67) | 2.46 (2.37-2.51) | 2.63 (2.57-2.70) | <.0001 |
| Postload calcemia (2.20 < N < 2.51 mmol/L) | 91 | 2.75 (2.63-2.85) | 2.61 (2.48-2.73) | 2.80 (2.72-2.92) | <.0001 |
| Fasting phosphatemia (0.85 < N < 1.31 mmol/L) | 91 | 0.78 (0.67-0.85) | 0.80 (0.69-0.85) | 0.77 (0.65-0.85) | .53 |
| CO2t (23 < N < 27 mmol/L) | 91 | 25.5 (23.7-27.2) | 26.8 (24.9-28.6) | 27.4 (25.2-28.8) | .45 |
| Preload PTH (12 < N < 75 ng/mL) | 91 | 80 (58-109) | 66 (55-94) | 82 (61-113) | .13 |
| Postload PTH (12 < N < 75 ng/mL) | 91 | 51 (40-76) | 43 (36-55) | 64 (43-85) | .003 |
| Delta PTH (%) | 91 | −31.8 (18-44) | −36.7 (24-50) | −28 (28-42) | .02 |
| Magnesemia (0.75 < N < 1.20 mmol/L) | 91 | 0.84 (0.80-0.89) | 0.85 (0.8-0.89) | 0.84 (0.79-0.89) | .9 |
| 25OH vitamin D (30 < N < 70 ng/mL) | 91 | 24 (17-30) | 26 (23-37) | 21 (12-25) | .04 |
| 1,25(OH)2 vitamin D (17 < N < 67 pg/mL) | 91 | 77 (60-96) | 77 (60-96) | 80 (62-101.5) | .81 |
| FGF23 (RU/mL) | 91 | 71 (52-101) | 77 (61-94) | 69 (52-105) | .76 |
| BALP (ng/mL) | 91 | 15.7 (11.7-23.9) | 15 (11-23) | 17 (12-24) | .29 |
| Preload TRP (N > 84%) | 91 | 85 (81-89) | 86 (81-90) | 85 (80-88) | .26 |
| Preload TmP/GFR (N > 0.77 mmol/L) | 91 | 0.65 (0.57-0.73) | 0.66 (0.59-0.76) | 0.69 (0.57-0.79) | .36 |
| Calciuria (mmol/day) | 91 | 7.2 (4.8-11.6) | 7.0 (4.9-11.2) | 7.8 (4.7-12.7) | .75 |
| Preload U Ca (mmol/mmol creatinine) | 91 | 0.51 (0.26-0.64) | 0.28 (0.21-0.60) | 0.54 (0.32-0.68) | .007 |
| Postload U Ca | 91 | 1.3 (0.8-1.9) | 1.2 (0.8-1.7) | 1.3 (0.9-2.0) | .35 |
| Delta U Ca (mmol/mmol creatinine)a | 91 | 0.8 (0.5-1.2) | 0.8 (0.5-1.2) | 0.8 (0.5-1.2) | .92 |
| Fasting U pH | 91 | 6.3 (5.7-6.6) | 6.3 (5.9-6.7) | 6.3 (5.7-6.6) | .44 |
| Fasting U FECa (%) | 91 | 2.3 (1.3-3.0) | 1.7 (1.1-2.6) | 2.5 (1.6-3.5) | .003 |
| Post load U FECa (%) | 91 | 5.9 (3.9-8.1) | 5.3 (3.7-8.0) | 6.0 (4.2-8.1) | .74 |
| U FeCa ratio (%)b | 91 | 177 (104-267) | 207 (137-402) | 171 (92-222) | .01 |
Abbreviations: BALP, bone alkaline phosphatase; CO2t, plasma bicarbonate; eGFR, estimated glomerular filtration rate using the CKD epi formula; FECa, fractional excretion of calcium (expressed in %); TmP/GFR, renal threshold phosphate concentration; TRP, tubular reabsorption of phosphate; U, urinary.
a Difference between postload and preload urine calcium (expressed in mmol/mmol creatinine);
b Difference between postload and preload U FECa/preload U FECa expressed in %.