Table 1. Summary of Reaction Conditions and DAR Distributions for Various mAb Isotypes (%).

mAb isotype	TCEP eq	(linker) siRNA eq	DAR0 (%)	DAR1 (%)	DAR ≥ 2 (%)	isolated DAR 1 yield (%)
hIgG1	2	(MCC) 1	25	57	18	46
hIgG2	6	(MCC) 1	27	40	33	34
hIgG4	1.75	(MCC) 1.25	47	22	31	16
hIgG4	1.75	(BisMal) 1.25	46	31	23	25
Rat IgG2a	4	(MCC) 1.15	38	41	21	36
Rabbit IgG	4	(MCC) 1.1	26	41	33	35