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Impact of DAR on AOC binding affinity, PK, muscle tissue delivery of PMO, and exon-skipping efficacy. (a) Impact of DAR on binding affinity. (b) Impact of DAR on PK in plasma. (c) Impact of DAR on PMO concentration in gastrocnemius tissue. (d) Impact of DAR on exon-skipping efficacy. For (b) to (d), n = 4 per group, error bars represent SEM.
