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. 2024 Aug 29;67(17):15012–15028. doi: 10.1021/acs.jmedchem.4c00577

Figure 1.

Figure 1

Synthesis of MLK3-targeting PROTACs: reaction conditions (a) aq LiOH, THF; (b) 1 to 10, HATU, DIPEA, DMF; (c) TFA/CH2Cl2.