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. 2005 May 25;33(9):3057–3064. doi: 10.1093/nar/gki612

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© The Author 2005. Published by Oxford University Press. All rights reserved

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Binding of 5mC/5mC, 5mC/BrC, 5mC/ClC, 5mC/ClU, 5mC/U and 5mC/BrU duplexes to varying concentrations of MBD from 0 to 256 nM. The following affinities for MBD to 5-halogenated pyrimidine lesions within a methyl-CpG sequence are observed: BrC ≥ ClC ≥ 5mC ≥ T > ClU ≫ U ≥ BrU ≫ C (5).