Table 1. Preclinical PK and Projected Human PK of Compound GNE-6893.

Species	LM CLhepa	Hep CLhepa	PPBb	CL	Vss (L/kg)	t1/2 (h)	%F
Mouse	61	47	94.7	34	1.8	1.7	37
Rat	32	29	90.6	39	2.2	1.3	30
Dogc	19	14	85.8	14	2.2	2.5	46
Cynod	29	9.9	88.4	14	1.9	1.9	53
Human (predicted)	14	5.9	95.5	(5.9)	(2.1)	(4.1)	(43)

^aLM and Hep clearance values (mL/min/kg) represent arithmetic means of two or more determinations.

^bPPB = plasma protein binding (%).

^cDog PK: Beagle, 0.5 mg/kg i.v. dose or 0.5 mg/kg p.o. dose, plasma clearance measured in mL/min/kg.

^dCynomolgus Monkey PK: 0.5 mg/kg i.v. dose or 0.5 mg/kg p.o. dose, plasma clearance measured in mL/min/kg.