Table 2.

EcoScale calculations and results for the synthesis of 2a and 3a [75].

synthesis of 2a
parameter	parameter details	penalty points
yield	91%	4.5
price of reaction components to obtain 10 mmol of product	1a	0
	DBSA	0
safety	DBSA	0
technical setup	common setup	0
temperature, time	heating, >1 h	3
workup and purification	classical chromatography	10
EcoScale score		82.5
synthesis of 3a
parameter	parameter details	penalty points
yield	90%	5
price of reaction components to obtain 10 mmol of product	1a	0
	PEG-400	0
	NaOH	0
safety	PEG-400	0
	NaOH	5 (dangerous for environment)
technical setup	common setup	0
temperature, time	heating, >1 h	3
workup and purification	classical chromatography	10
EcoScale score		77.0