Fig. 6.

Some typical biomedical applications of PepNzymes. (A) CuS/PAF-26 microneedles for treating deep-cutaneous fungal infections without inducing drug resistance, using hyaluronic acid (HA) and sodium carboxymethylcellulose (CMC-Na) to deliver copper sulfide (CuS) nanozyme and antimicrobial peptide (PAF-26). Reproduced with permission from Ref. [102], copyright 2023, American Chemical Society. (B) Multifunctional nanohybrid peptide hydrogel for enhanced intervertebral disc repair, created through hierarchical self-assembly of peptide amphiphile with biodegradable two-dimensional nanomaterials. Reproduced with permission from Ref. [105], copyright 2023, American Chemical Society. (C) PMR nano-sonosensitizers for MRI-guided and catalytic oxygen generation-enhanced SDT against cancer. Reproduced with permission from Ref. [108], copyright 2018, American Chemical Society. (D) Alkaline phosphatase-like peptide nanofibers for osteogenic differentiation. Reproduced with permission from Ref. [110], copyright 2015, American Chemical Society.