Estimated oral bioavailability and BBB permeability for bioactive bicyclic-based Glypromate conjugates and Glypromate using SwissADME,⁴⁸ ADMETsar 3.0,⁴⁹ and LightBBB⁵⁰ cheminformatic resources.

	Glypromate	14a	14c	15a	17a	18c
Log Po/w48	−1.98	1.36	1.05	1.99	1.47	1.72
TPSA (Å2)49	150.03	130.83	130.83	108.05	130.83	108.05
Bioavailability score48	0.11	0.55	0.55	0.55	0.55	0.55
HIA (%)49	9	69.1	57.9	86.7	71.8	86.2
Log BB50	−1.08	−0.72	−0.83	−0.78	−0.68	−0.78