HRV protomer, WIN 52084, and VP1 structure. (A) Ribbon representation of the HRV14 protomer, with WIN 52084 shown as space-filling spheres (magenta). The protomer comprises VP1 (blue), VP2 (green), VP3 (red), and VP4 (yellow). The icosahedral 5-fold axis lies between the VP3 terminus and VP1 in the upper right corner and is ≈10–15° away from perpendicular to the plane of view. (B) Chemical structure of WIN 52084. (C) van der Waals space-filling representation of VP1 (blue) and the C terminus of VP3 (red). WIN 52084 is present but not visible.