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. 2005 May 16;102(21):7736–7741. doi: 10.1073/pnas.0409818102

Fig. 4.

Fig. 4.

The resolution of GN by CK2 inhibition is closely associated with its antiproliferative, antiinflammatory, and antifibrotic effects. (a) TUNEL staining (Top) and immunohistochemical staining for Ki67 (Middle) and phospho-ERK (Bottom) of the renal tissue in anti-Thy1 GN rats. (Original magnification: ×120. Bar, 100 μm.) (b) Real-time PCR analysis of expression of ERK pathway related transcription factors (c-fos, Egr-1, and Elk-1), NF-κB-regulated proinflammatory genes (TNFα and MCP-1), extracellular matrix genes (collagen IVα1 and fibronectin), and their promoting factors (connective tissue growth factor, TGFβ1, and platelet-derived growth factor B) in the renal cortex of anti-Thy1 GN rats. Data are shown as mean ± SEM.; n = 5 animals. *, P < 0.05; **, P < 0.01 compared with the control group; ##, P < 0.01 compared with the anti-Thy1 group. ColIVα1, collagen IVα1; Fn, fibronectin; CTGF, connective tissue growth factor; PDGF-B, platelet-derived growth factor B.