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Deletion of DGKι enhances Ras-dependent tumor formation. TG.AC+/dgki+/+ or TG.AC+/dgki–/– animals were either treated with PMA three times per week for 8 weeks (A, n = 8 per condition) or subjected to full-thickness wounding (B, n = 22–25 per condition, tumors assessed at 20 weeks). *, P < 0.05 as compared with vehicle control animals. (C) Using affinity precipitation, levels of active Rap1 were determined in spontaneous mouth tumors from one TG.AC+/dgki+/+ or one TG.AC+/dgki–/– animal.
