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High virulence of attenuated RVFV strains in IFN-deficient mice. IFNAR−/− mice lacking the receptor for IFN-α/β (solid triangles) and genotype-matched normal mice (open circles) were infected intraperitoneally with 104 PFU of either wild-type virus ZH548 (A), attenuated strain MP12 (B), or attenuated strain clone 13 (C). Survival was assessed daily for up to 21 days.
