Table 3.
Observed correlations between PROMIS measures and myositis outcome measures according to diagnosis
| Observed r in full cohort | Dermatomyositis (n=65) | Non-Dermatomyositisa (n=70) | |||
|---|---|---|---|---|---|
| n | Pearson’s r | n | Pearson’s r | ||
|
| |||||
| PROMIS Pain Interference | |||||
| Age | −0.14 | 63 | −0.16 | 66 | −0.10 |
| Patient global | 0.46 | 52 | 0.49 | 52 | 0.44 |
| Physician global | 0.34 | 57 | 0.21 | 57 | 0.46 |
| MMT | −0.21 | 57 | −0.29 | 57 | −0.14 |
| Creatine kinase | 0.01 | 62 | 0.02 | 66 | 0.06 |
| HAQ-DI | 0.29+ | 15 | 0.68+ | 25 | 0.05+ |
| PROMIS Fatigue | |||||
| Age | −0.16 | 65 | 0.0 | 70 | −0.3 |
| Patient global | 0.54 | 52 | 0.42 | 56 | 0.62 |
| Physician global | 0.51 | 57 | 0.31 | 61 | 0.64 |
| MMT | −0.41 | 58 | −0.38 | 61 | −0.43 |
| Creatine kinase | 0.20 | 64 | 0.12 | 70 | 0.30 |
| HAQ-DI | 0.55+ | 15 | 0.65+ | 28 | 0.49+ |
| PROMIS Physical Function | |||||
| Age | 0.04 | 63 | −0.02 | 66 | 0.10 |
| Patient global | −0.64 | 52 | −0.55 | 52 | −0.73 |
| Physician global | −0.56 | 57 | −0.39 | 57 | −0.69 |
| MMT | 0.49 | 57 | 0.39 | 57 | 0.57 |
| Creatine kinase | −0.18 | 62 | −0.10 | 66 | −0.27 |
| HAQ-DI | −0.83+ | 15 | −0.91+ | 25 | −0.76+ |
Non-dermatomyositis includes immune-mediated necrotizing myopathy, polymyositis, anti-synthetase syndrome, and overlap myositis
Spearman’s rho
Creatine kinase =log of creatine kinase level/upper limit of normal; HAQ-DI: Health Assessment Questionnaire Disability Index; MMT: Manual muscle testing; USA: United States of America