FIGURE 1.

MTAP immunostaining of normal tissues. The panels show MTAP immunostaining of variable intensity for almost every cell type in each tissue. MTAP staining was particularly intense in interfollicular lymphocytes of a lymph node (A), urothelial cells in the urinary bladder (B), and in cytotrophoblast cells of the placenta (C). A moderate to strong MTAP staining was also seen in myometrium cells of the uterus (D), tubular cells of the kidney (E), and in spermatogonia and Leydig cells of the testis (F). MTAP staining was only weak in maturing spermatids of the testis (F), hepatocytes of the liver (G), and in colorectal epithelial cells (H).