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. 2024 Aug 12;48(10):1245–1258. doi: 10.1097/PAS.0000000000002297

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Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.

This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/

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MTAP loss in tumors with homozygous 9p21 deletion. MTAP staining was completely lacking in tumor cells of an (epithelioid) malignant mesothelioma (A), a urothelial carcinoma of the renal pelvis (B), a mucinous ovarian carcinoma (C), a serous high-grade ovarian carcinoma (D), a malignant melanoma (E), a recurrent adenocarcinoma of the prostate (F), a colorectal adenocarcinoma (G), and a ductal adenocarcinoma of the pancreas (H). Distinct MTAP positivity of intermingled stroma cells and of non-neoplastic epithelial cells serves as a positive internal control.